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@Article{HurtadoWQMCTDSMHTT:2020:SiPrOb,
               author = "Hurtado, Carolina Ramos and Wachesk, Cristiane da Costa and 
                         Queiroz, Rafaela Campos and Macedo, Erenilda Ferreira de and 
                         Correia, Rebeca Falc{\~a}o Borja de Oliveira and Taiariol, 
                         Thalita Sani and Diniz, Milton Faria and Santos, Alexandre Martins 
                         Isaias dos and Montanheiro, Thais Larissa do Amaral and Hurtado, 
                         Gabriela Ramos and Trava-Airoldi, Vladimir Jesus and Tada, Dayane 
                         Batista",
          affiliation = "{Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and {Instituto 
                         Nacional de Pesquisas Espaciais (INPE)} and {Instituto Nacional de 
                         Pesquisas Espaciais (INPE)} and {Instituto de Aeron{\'a}utica e 
                         Espa{\c{c}}o (IAE)} and {Universidade Federal de S{\~a}o Paulo 
                         (UNIFESP)} and {Instituto Tecnol{\'o}gico de Aeron{\'a}utica 
                         (ITA)} and {Universidade Estadual Paulista (UNESP)} and {Instituto 
                         Nacional de Pesquisas Espaciais (INPE)} and {Universidade Federal 
                         de S{\~a}o Paulo (UNIFESP)}",
                title = "A simple procedure to obtain nanodiamonds from leftover of HFCVD 
                         system for biological application",
              journal = "SN Applied Sciences",
                 year = "2020",
               volume = "2",
               number = "352",
                pages = "2",
             keywords = "Nanodiamonds · Ultrasonic cavitation · CVD diamond · 
                         Functionalization · Cytotoxicity · Colloidal suspension.",
             abstract = "Nanodiamonds (NDs) are amongst the most investigated carbon-based 
                         nanostructures due to their chemical stability and favorable 
                         mechanical properties. Despite the number of works on methods for 
                         NDs production, one of the main challenges is to achieve their 
                         colloidal stability in aqueous suspension. Additionally, NDs are 
                         normally obtained by expensive, complex and time-consuming 
                         process. Herein, it was presented a facile method to obtain NDs in 
                         aqueous suspension by using columnar structure diamond from 
                         Hot-Filament Chemical Vapour Deposition reactor (HFCVD). CVD 
                         diamond leftover thick flm from CVDVale Company was used. 
                         Therefore, this method has the advantage of being not only 
                         practical but also cost-efective since it brings a proftable use 
                         of CVD diamond leftover. The Diamond thick flm was submitted to 
                         ultrasonic cavitation in the presence and absence of ZrO2 
                         microbeads in aqueous medium. The NDs hydrodynamic diameter and 
                         the stability in aqueous suspension were monitored by light 
                         scattering, size and morphology were analyzed by transmission 
                         electronic microscopy. Considering the wide application of NDs in 
                         biomedical devices, cytotoxicity of aqueous suspensions of NDs was 
                         evaluated against murine embryonic fbroblast cells. Furthermore, 
                         NDs were functionalized with hydrogen and carboxyl groups. NDs 
                         aqueous suspension of straight size distribution was obtained even 
                         in the absence of ZrO2 beads, indicating that they may be 
                         dispensable in order to decrease NDs size. NDs of average 
                         hydrodynamic diameter of 22 nm and \−35 mV of 
                         Zeta-potential were obtained after ultrasonic cavitation followed 
                         by 2 h of centrifugation, not demonstrating cytotoxicity to cells 
                         at very low (0.050.5 \μg/mL) nor at higher concentrations 
                         (116 \μg/mL). Nevertheless, NDs showed a moderate 
                         cytotoxicity at intermediary concentration range (0.52.2 
                         \μg/mL). From our knowledge, this is the frst work that 
                         reports on a facile method for providing NDs aqueous suspension 
                         with high colloidal stability from HFCVD diamond leftover.",
                  doi = "10.1007/s42452-020-1967-1",
                  url = "http://dx.doi.org/10.1007/s42452-020-1967-1",
                 issn = "2523-3963",
                label = "lattes: 3455204481678421 11 HurtadoWQMFTDSMHAT:2020:SiPrOb",
             language = "pt",
           targetfile = "hurtado_simple.pdf",
        urlaccessdate = "28 mar. 2024"
}


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